major basic protein การใช้

• Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues.
• The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
• Structurally the major basic protein ( MBP ) is similar to lectins ( sugar-binding proteins ), and has a fold similar to that seen in C-type lectins.
• Cardiac damage caused by the damaging effects of eosinophil granule proteins ( ex . major basic protein ) is known as Loeffler endocarditis and can be caused by idiopathic eosinophilia or eosinophilia in response to parasitic infection.
• Major basic protein induces mast cell and basophil degranulation, and is implicated in proliferation of T cells, suppress antibody production by B cells, induce degranulation by mast cells, and stimulate fibroblast cells to secrete mucus and glycosaminoglycan.